Ken A. Brameld
Publications by Year
Research Areas
Fibroblast Growth Factor Research, Chronic Lymphocytic Leukemia Research, HIV/AIDS drug development and treatment, Click Chemistry and Applications, Hepatitis C virus research
Most-Cited Works
- → Prolonged and tunable residence time using reversible covalent kinase inhibitors(2015)426 cited
- → Small Molecule Conformational Preferences Derived from Crystal Structure Data. A Medicinal Chemistry Focused Analysis(2008)367 cited
- → The pKBHX Database: Toward a Better Understanding of Hydrogen-Bond Basicity for Medicinal Chemists(2009)330 cited
- → Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease(2021)113 cited
- → Substrate assistance in the mechanism of family 18 chitinases: theoretical studies of potential intermediates and inhibitors 1 1Edited by B. Honig(1998)111 cited
- → The role of enzyme distortion in the single displacement mechanism of family 19 chitinases(1998)108 cited
- → The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences(1999)107 cited
- → Distance Dependent Hydrogen Bond Potentials for Nucleic Acid Base Pairs from ab Initio Quantum Mechanical Calculations (LMP2/cc-pVTZ)(1997)101 cited
- → Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors(2017)95 cited
- → Substrate Distortion to a Boat Conformation at Subsite −1 Is Critical in the Mechanism of Family 18 Chitinases(1998)91 cited