Andrew Cooke
Exscien (United States)(US)
Publications by Year
Research Areas
Cancer Mechanisms and Therapy, Nuclear Receptors and Signaling, Growth Hormone and Insulin-like Growth Factors, Melanoma and MAPK Pathways, Enzyme function and inhibition
Most-Cited Works
- → Discovery of OSI-906: A Selective and Orally Efficacious Dual Inhibitor of the IGF-1 Receptor and Insulin Receptor(2009)307 cited
- → A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo(2007)147 cited
- → OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models(2006)80 cited
- → Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors(2007)72 cited
- → SAR, Pharmacokinetics, Safety, and Efficacy of Glucokinase Activating 2-(4-Sulfonylphenyl)-N-thiazol-2-ylacetamides: Discovery of PSN-GK1(2008)54 cited
- → A Mobile Climbing Robot for High Precision Manufacture and Inspection of Aerostructures(2005)42 cited
- → A three-step tandem process for the synthesis of bicyclic γ-lactams(2010)34 cited
- → 1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors(2006)32 cited
- → Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics(2013)26 cited
- → Imidazo[1,5-a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2(2011)22 cited