Nikolai Makukhin
Target (United States)(US)University of Dundee(GB)
Publications by Year
Research Areas
Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Multiple Myeloma Research and Treatments, Peptidase Inhibition and Analysis, Cyclopropane Reaction Mechanisms
Most-Cited Works
- → Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity(2021)228 cited
- → Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2(2022)162 cited
- → Mechanism of degrader-targeted protein ubiquitinability(2024)56 cited
- → A Ratiometric Fluorescent Probe for Imaging of the Activity of Methionine Sulfoxide Reductase A in Cells(2016)46 cited
- → Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase(2019)40 cited
- → Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma(2021)39 cited
- → Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2(2023)35 cited
- → Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues(2020)31 cited
- → Synthetic routes to 3(5)-phosphonylated pyrazoles(2015)28 cited
- → Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera(2024)24 cited