James B. Coutcher
Pfizer (United States)(US)
Publications by Year
Research Areas
Cannabis and Cannabinoid Research, Aldose Reductase and Taurine, Pancreatic function and diabetes, Fluorine in Organic Chemistry, Metabolism and Genetic Disorders
Most-Cited Works
- → A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy(2006)131 cited
- → A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one(2003)68 cited
- → A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and Congeners(2005)65 cited
- → Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors: Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-Pyrimidines(2001)48 cited
- → Dietary choline supplementation increases the density of nicotine binding sites in rat brain.(1992)30 cited
- → Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4-[2-1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid Dimethylamide(2001)26 cited
- → A Sorbitol Dehydrogenase Inhibitor of Exceptional in Vivo Potency with a Long Duration of Action: 1-(R)-{4-[4-(4,6-Dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl}ethanol(2002)19 cited
- → SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711(2002)7 cited
- → ChemInform Abstract: Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4‐[2‐(1R‐Hydroxy‐ethyl)‐pyrimidin‐4‐yl]‐piperazine‐1‐sulfonic Acid Dimethylamide.(2001)