Federica Ferrigno
IRBM Science Park(IT)
Publications by Year
Research Areas
Histone Deacetylase Inhibitors Research, Protein Degradation and Inhibitors, Peptidase Inhibition and Analysis, DNA Repair Mechanisms, PARP inhibition in cancer therapy
Most-Cited Works
- → Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors(2009)308 cited
- → Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain(2008)303 cited
- → 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors(2008)64 cited
- → Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy(2009)61 cited
- → 2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors(2008)53 cited
- → Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs(2016)40 cited
- → Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2(2011)37 cited
- → Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides(2018)32 cited
- → Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction(2020)28 cited
- → Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors(2008)24 cited