Leslie J. Street
University of Cape Town(ZA)
Publications by Year
Research Areas
Malaria Research and Control, Phenothiazines and Benzothiazines Synthesis and Activities, Neuroscience and Neuropharmacology Research, Computational Drug Discovery Methods, Synthesis and biological activity
Most-Cited Works
- → Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype(2000)938 cited
- → Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase(2017)267 cited
- → Evidence for a Significant Role of α3-Containing GABAAReceptors in Mediating the Anxiolytic Effects of Benzodiazepines(2005)244 cited
- → UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria(2018)136 cited
- → Selective, Orally Active γ-Aminobutyric Acid A α5 Receptor Inverse Agonists as Cognition Enhancers(2004)104 cited
- → Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum(2013)79 cited
- → Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors(1993)75 cited
- → Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle(2016)58 cited
- → Structure–Activity-Relationship Studies around the 2-Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral in Vivo Activity(2013)49 cited
- → Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1(2014)48 cited