Jan Snoeys
Johnson & Johnson (United States)(US)
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Drug-Induced Hepatotoxicity and Protection, Hepatitis C virus research, Virus-based gene therapy research
Most-Cited Works
- → Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease(2016)690 cited
- → Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective(2015)466 cited
- → Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling(2008)427 cited
- → Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study(2018)302 cited
- → Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models(2019)241 cited
- → The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death(2015)151 cited
- → Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations(2019)139 cited
- → Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines(2020)125 cited
- → Physiologically‐Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective(2020)119 cited
- → Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches(2018)114 cited