Kevin J. Embrey
AstraZeneca (Brazil)(BR)
Publications by Year
Research Areas
PARP inhibition in cancer therapy, Protein Kinase Regulation and GTPase Signaling, DNA and Nucleic Acid Chemistry, Enzyme Structure and Function, Protein Structure and Dynamics
Most-Cited Works
- → Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia(2018)480 cited
- → Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation(2015)262 cited
- → Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents(2011)134 cited
- → Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs(2021)131 cited
- → Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation(2015)118 cited
- → Sequence-specific interaction of Hoescht 33258 with the minor grooVe of an adenine-tract DNA duplex studied in solution by1H NMR spectroscopy(1990)107 cited
- → KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe(2019)93 cited
- → Prevention of MKK6-Dependent Activation by Binding to p38α MAP Kinase(2005)89 cited
- → Interaction of Hoechst 33258 with the minor groove of the A + T‐rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopy(1993)84 cited
- → Structure-based design of protein tyrosine phosphatase-1B inhibitors(2005)75 cited