Nichole O’Connell
AstraZeneca (United States)(US)
Publications by Year
Research Areas
Protein Structure and Dynamics, Cancer-related Molecular Pathways, Ubiquitin and proteasome pathways, Enzyme Structure and Function, Cancer therapeutics and mechanisms
Most-Cited Works
- → Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6(2018)136 cited
- → Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies(2020)100 cited
- → Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors(2017)78 cited
- → The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme(2012)75 cited
- → Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo(2016)54 cited
- → Structure‐Based Design of Selective Noncovalent CDK12 Inhibitors(2017)52 cited
- → NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes(2012)44 cited
- → Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion(2009)26 cited
- → Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement(2021)24 cited
- → Protein Ligand Interactions Using Surface Plasmon Resonance(2021)23 cited