C. Lerner
Roche (Switzerland)(CH)
Publications by Year
Research Areas
Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Eicosanoids and Hypertension Pharmacology, Computational Drug Discovery Methods, Chemical Synthesis and Analysis
Most-Cited Works
- → A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics(2005)294 cited
- → A Robust Platform for the Synthesis of New Tetracycline Antibiotics(2008)129 cited
- → A Real-World Perspective on Molecular Design(2016)120 cited
- → Machine learning-powered antibiotics phenotypic drug discovery(2019)109 cited
- → Safety screening in early drug discovery: An optimized assay panel(2019)82 cited
- → Synthesis of Novel Nonpeptidic Thrombin Inhibitors(2000)69 cited
- → X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann–La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing.(2001)62 cited
- → Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity(2002)57 cited
- → A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro(2016)52 cited
- → X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity(2001)51 cited