Paul Erdman

Publications by Year

Research Areas

Cytokine Signaling Pathways and Interactions, Synthesis and biological activity, Protein Degradation and Inhibitors, Multiple Myeloma Research and Treatments, NF-κB Signaling Pathways

Most-Cited Works

• → Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models(2018)148 cited
• → Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches(2009)105 cited
• → Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3‘,5‘-bis(trifluoromethyl)phenyl)carboxamide](2000)80 cited
• → The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen(2017)59 cited
• → Structure–Activity Relationship Studies of Ethyl 2-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: An Inhibitor of AP-1 and NF-κB Mediated Gene Expression(2002)45 cited
• → 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3‘,5‘-bis(trifluoromethyl)phenyl)- carboxamide: A Potent Inhibitor of NF-κB- and AP-1-Mediated Gene Expression Identified Using Solution-Phase Combinatorial Chemistry(1998)44 cited
• → The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of In vitro and In vivo studies(2003)41 cited
• → Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001(2021)37 cited
• → Design and Synthesis of Pyrrolidine-based Fragments That Sample Three-dimensional Molecular Space(2019)33 cited
• → Novel inhibitors of AP-1 and NF-κB mediated gene expression: structure–activity relationship studies of ethyl 4-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carboxylate(2000)31 cited