James D. Clark
VA Palo Alto Health Care System(US)Stanford Medicine(US)Stanford University(US)
Publications by Year
Research Areas
Protein Kinase Regulation and GTPase Signaling, Cytokine Signaling Pathways and Interactions, Pain Mechanisms and Treatments, Rheumatoid Arthritis Research and Therapies, Inflammatory mediators and NSAID effects
Most-Cited Works
- → A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP(1991)1,700 cited
- → Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases(2014)581 cited
- → Cytosolic phospholipase A2(1995)523 cited
- → Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.(1990)429 cited
- The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis.(2016)
- → Crystal Structure of Human Cytosolic Phospholipase A2 Reveals a Novel Topology and Catalytic Mechanism(1999)366 cited
- → Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.