Sean W. Fanning
Loyola University Chicago(US)
Publications by Year
Research Areas
Estrogen and related hormone effects, Computational Drug Discovery Methods, Advanced Breast Cancer Therapies, Chemical Synthesis and Analysis, Monoclonal and Polyclonal Antibodies Research
Most-Cited Works
- → ESR1 ligand-binding domain mutations in hormone-resistant breast cancer(2013)1,235 cited
- → Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists(2016)364 cited
- → Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation(2016)299 cited
- → The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells(2018)92 cited
- → Stapled Peptides with γ‐Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction(2016)90 cited
- → Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer(2021)84 cited
- → A combinatorial histidine scanning library approach to engineer highly pH‐dependent protein switches(2011)78 cited
- → An anti‐hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop(2011)68 cited
- → Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity(2018)64 cited
- → Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells(2022)52 cited