John I. Trujillo
Pfizer (United States)(US)
Publications by Year
Research Areas
Cyclopropane Reaction Mechanisms, Catalytic C–H Functionalization Methods, Synthesis and Catalytic Reactions, Fluorine in Organic Chemistry, Chemical Synthesis and Analysis
Most-Cited Works
- → Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition(2016)191 cited
- → Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S )-2,2-Difluorocyclopropyl)((1 R ,5 S )-3-(2-((1-methyl-1 H -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)(2018)170 cited
- → The Olefin Metathesis Approach to Epothilone A and Its Analogues(1997)167 cited
- → Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans(2017)160 cited
- → Effect of the acidic component on the Mitsunobu inversion of a sterically hindered alcohol(1994)159 cited
- → Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay(2017)159 cited
- → PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor(2019)157 cited
- → Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)(2007)137 cited
- → Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors(2018)74 cited
- → Design, synthesis and biological evaluation of carbohydrate-based mimetics of cRGDFV(1997)71 cited