James A. Southers
Pfizer (United States)(US)
Publications by Year
Research Areas
Peroxisome Proliferator-Activated Receptors, Regulation of Appetite and Obesity, Chemical Synthesis and Analysis, Metabolism, Diabetes, and Cancer, Asymmetric Synthesis and Catalysis
Most-Cited Works
- → Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes(2014)88 cited
- → Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists(2009)51 cited
- → Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure(2013)47 cited
- → The discovery of novel calcium sensing receptor negative allosteric modulators(2009)41 cited
- → Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors(2012)33 cited
- → The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems(2016)21 cited
- → Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase(2015)18 cited
- → Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors(2012)18 cited
- → Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors(2012)17 cited
- → Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists(2010)13 cited