Jian Jeffrey Chen
Sun Yat-sen University(CN)Shanghai Jiao Tong University(CN)Shanghai Chest Hospital(CN)Tongren Hospital(CN)Shanghai Tenth People's Hospital(CN)Shanghai Sixth People's Hospital(CN)Xi'an Jiaotong University(CN)
Publications by Year
Research Areas
Coagulation, Bradykinin, Polyphosphates, and Angioedema, Neuropeptides and Animal Physiology, Computational Drug Discovery Methods, Chemical Synthesis and Analysis, Peptidase Inhibition and Analysis
Most-Cited Works
- → Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors(2019)691 cited
- In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.(2001)
- → Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways(2019)132 cited
- → Fragmentation of substituted acetophenones and halobenzophenone ketyls. Calibration of a mechanistic probe(1991)82 cited
- → On the mechanism of the reduction of .alpha.-haloketones by 1,3-dimethyl-2-phenylbenzimidazoline. Reduction by a SET (single electron transfer)-hydrogen atom abstraction chain mechanism(1989)61 cited
- → Discovery of TRPM8 Antagonist (S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine(2018)61 cited