Michael D. Aleo
Publications by Year
Research Areas
Drug-Induced Hepatotoxicity and Protection, Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Computational Drug Discovery Methods, Pharmacological Effects and Toxicity Studies
Most-Cited Works
- → Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States(2011)688 cited
- → Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump(2014)213 cited
- → Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans(2012)206 cited
- → Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanisticin vitroAssays(2015)139 cited
- → Comparisons betweenin vitrowhole cell imaging andin vivozebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development(2012)100 cited
- → Mitochondrial dysfunction is an early event in ochratoxin a but not oosporein toxicity to rat renal proximal tubules(1991)85 cited
- → Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs(2018)79 cited
- → Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies(2010)65 cited
- → Differences in enzymatic and mechanical isolated rabbit renal proximal tubules: Comparison in long-term incubation(1990)60 cited
- → Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential(2019)58 cited