Terry L. Nechuta
Merck & Co., Inc., Rahway, NJ, USA (United States)(US)
Publications by Year
Research Areas
Chemical Synthesis and Analysis, Cholinesterase and Neurodegenerative Diseases, Cell Adhesion Molecules Research, Receptor Mechanisms and Signaling, Phosphodiesterase function and regulation
Most-Cited Works
- Inhibition of angiogenesis and tumor growth by SCH221153, a dual alpha(v)beta3 and alpha(v)beta5 integrin receptor antagonist.(2001)
- → Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors(2009)102 cited
- → Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity(1997)80 cited
- → 2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors(2006)39 cited
- Targeting integrins alpha v beta 3 and alpha v beta 5 for blocking tumor-induced angiogenesis.(2000)
- → Targeting Integrins αvβ3 and αvβ5 for Bloking Tumor-Induced Angiogenesis(2000)34 cited
- → The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia(2011)33 cited
- → T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones—optimization, design and synthesis(2010)27 cited
- → Construction of a family of biphenyl combinatorial libraries: Structure-activity studies utilizing libraries of mixtures(1998)23 cited
- → Combinatorial libraries based on a novel and readily accessible “centroid” scaffold(1998)19 cited