Douglas A. Whittington
Tango Therapeutics (United States)(US)Io Therapeutics (United States)(US)
Publications by Year
Research Areas
PARP inhibition in cancer therapy, Ubiquitin and proteasome pathways, PI3K/AKT/mTOR signaling in cancer, Cancer Immunotherapy and Biomarkers, interferon and immune responses
Most-Cited Works
- → Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors(2019)690 cited
- → AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies(2018)409 cited
- → Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells(2001)321 cited
- → Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase(2002)320 cited
- → 2.4 Å Crystal Structure of an Oxaliplatin 1,2-d(GpG) Intrastrand Cross-Link in a DNA Dodecamer Duplex(2001)206 cited
- → Crystal Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) Demonstrating Geometrical Variability at the Dinuclear Iron Active Site(2001)