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Paul R. McGuirk | doi.page

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Paul R. McGuirk

OMV Petrom (Romania)(RO)Aeromics (United States)(US)

Publications by Year

Research Areas

Cancer therapeutics and mechanisms, Antibiotics Pharmacokinetics and Efficacy, Ion Transport and Channel Regulation, Synthesis and Biological Evaluation, Asymmetric Synthesis and Catalysis

Most-Cited Works

→ DNA knots reveal a chiral organization of DNA in phage capsids(2005)246 cited
→ Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage(1991)145 cited
→ Highly stereoselective synthesis of trisubstituted olefins via addition of alkylcopper complexes to acetylenes(1979)111 cited
→ Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group(1992)94 cited
→ Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents(1989)93 cited
→ New Quinolone Compounds from Pseudonocardia sp. with Selective and Potent Anti-Helicobacter pylori Activity: Taxonomy of Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities.(1998)68 cited

→ Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential(1993)

64 cited

→ Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury(2019)62 cited

→ Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine(1992)47 cited

→ Total synthesis of (+)-phyllanthocin(1982)42 cited