Laurence Biggers
Southwestern Medical Center(US)The University of Texas Southwestern Medical Center(US)
Publications by Year
Research Areas
Genetic and Kidney Cyst Diseases, Renal and related cancers, Vascular Malformations and Hemangiomas, MicroRNA in disease regulation, Hedgehog Signaling Pathway Studies
Most-Cited Works
- → PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression(2022)69 cited
- → Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression(2020)63 cited
- → Enhancer and super-enhancer landscape in polycystic kidney disease(2022)25 cited
- → Molecular dynamics simulations of an engineered T4 lysozyme exclude helix to sheet transition, and provide insights into long distance, intra‐protein switchable motion(2019)2 cited
- → Equilibrium landscape of ingress/egress channels and gating residues of the Cytochrome P450 3A4(2024)2 cited
- → Disruption of a six-nucleotide miRNA motif improves PKD1 dosage and ameliorates polycystic kidney disease(2025)1 cited
- → Precise Editing of the Central Six Nucleotides in the Pkd1-3’UTR miR-17 Binding Motif Is Sufficient to Restore Pkd1 and Slow PKD Progression(2025)
- → Development of a Pkd1 mRNA Stabilizing Oligonucleotide for the Treatment of ADPKD(2024)