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Matthew J. LaMarche

Sanofi (United States)(US)

Publications by Year

Research Areas

Protein Tyrosine Phosphatases, Galectins and Cancer Biology, Melanoma and MAPK Pathways, Cancer Treatment and Pharmacology, Bioactive Compounds and Antitumor Agents

Most-Cited Works

→ Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases(2016)909 cited
→ Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor(2016)286 cited
→ Evolution of a Gram-Scale Synthesis of (+)-Discodermolide(2000)236 cited
→ Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer(2020)210 cited
→ SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors(2018)200 cited
→ Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu(2009)168 cited

→ Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition(2018)

163 cited

→ Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling(2020)159 cited

→ Dual Allosteric Inhibition of SHP2 Phosphatase(2018)127 cited

→ Gram-Scale Synthesis of (+)-Discodermolide(1999)121 cited