Matthew D. Troutman
Pfizer (United States)(US)
Publications by Year
Research Areas
Drug Transport and Resistance Mechanisms, Pharmacogenetics and Drug Metabolism, Mass Spectrometry Techniques and Applications, Analytical Chemistry and Chromatography, Pharmacological Effects and Toxicity Studies
Most-Cited Works
- → Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes(2010)479 cited
- → In Vitro P-glycoprotein Assays to Predict the in Vivo Interactions of P-glycoprotein with Drugs in the Central Nervous System(2007)441 cited
- → THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL(2004)440 cited
- → Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination(2010)316 cited
- → Development of a new permeability assay using low‐efflux MDCKII cells(2011)314 cited
- → Physicochemical Determinants of Human Renal Clearance(2009)206 cited
- → Novel Experimental Parameters to Quantify the Modulation of Absorptive and Secretory Transport of Compounds by P-Glycoprotein in Cell Culture Models of Intestinal Epithelium(2003)160 cited
- → Species Independence in Brain Tissue Binding Using Brain Homogenates(2011)159 cited
- → Efflux Ratio Cannot Assess P-Glycoprotein-Mediated Attenuation of Absorptive Transport: Asymmetric Effect of P-Glycoprotein on Absorptive and Secretory Transport Across Caco-2 Cell Monolayers(2003)155 cited
- → Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design(2012)152 cited