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Edward McDonald | doi.page

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Edward McDonald

Publications by Year

Research Areas

Porphyrin Metabolism and Disorders, Heat shock proteins research, Porphyrin and Phthalocyanine Chemistry, Enzyme Structure and Function, Endoplasmic Reticulum Stress and Disease

Most-Cited Works

→ NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis(2008)476 cited
→ 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer(2007)442 cited
→ Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941(2009)271 cited
→ Biosynthesis of the pigments of life: formation of the macrocycle(1980)232 cited
→ Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design(2005)231 cited
→ Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity(2005)222 cited

→ The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors(2005)

219 cited

→ Identification of Novel Small Molecule Inhibitors of Hypoxia-Inducible Factor-1 That Differentially Block Hypoxia-Inducible Factor-1 Activity and Hypoxia-Inducible Factor-1α Induction in Response to Hypoxic Stress and Growth Factors(2005)146 cited

→ Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues(2007)142 cited

→ Discovery and Development of Pyrazole-Scaffold Hsp90 Inhibitors(2006)141 cited