David C. McGowan
Publications by Year
Research Areas
Hepatitis C virus research, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Hepatitis B Virus Studies, HIV/AIDS drug development and treatment
Most-Cited Works
- → Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350(2008)136 cited
- → Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity(2006)67 cited
- → Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)(2020)66 cited
- → Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids(2015)62 cited
- → Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity(2006)61 cited
- → 1,5-Benzodiazepine inhibitors of HCV NS5B polymerase(2009)60 cited
- → Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase(2009)60 cited
- → Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR(2007)48 cited
- → Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties(2007)41 cited
- → Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus(2016)40 cited