Louis V. LaFrance
South College(US)
Publications by Year
Research Areas
Epigenetics and DNA Methylation, Cancer-related gene regulation, Cancer-related Molecular Pathways, RNA modifications and cancer, PI3K/AKT/mTOR signaling in cancer
Most-Cited Works
- → EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations(2012)1,779 cited
- → Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells(2005)425 cited
- → Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2(2012)375 cited
- → 1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR(2004)166 cited
- → Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo(2006)162 cited
- → Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase(2008)155 cited
- → Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design(2006)76 cited
- → Development and Validation of Reagents and Assays for EZH2 Peptide and Nucleosome High-Throughput Screens(2012)60 cited
- → Substituted 1,4‐Benzodiazepine‐2,5‐diones as α‐Helix Mimetic Antagonists of the HDM2‐p53 Protein–Protein Interaction(2006)45 cited
- → Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening(2022)17 cited