Jacob D. Aguirre
Friedrich Miescher Institute(CH)
Publications by Year
Research Areas
Ubiquitin and proteasome pathways, Autophagy in Disease and Therapy, Protein Degradation and Inhibitors, Parkinson's Disease Mechanisms and Treatments, DNA Repair Mechanisms
Most-Cited Works
- → Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis(2015)219 cited
- → A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease(2013)150 cited
- → Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation(2016)90 cited
- → Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation(2019)78 cited
- → UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability(2023)67 cited
- → Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation(2018)59 cited
- → Orphan quality control shapes network dynamics and gene expression(2023)53 cited
- → Generation of phospho‐ubiquitin variants by orthogonal translation reveals codon skipping(2016)35 cited
- → Impact of altered phosphorylation on loss of function of juvenile Parkinsonism–associated genetic variants of the E3 ligase parkin(2018)34 cited
- → Capturing the catalytic intermediates of parkin ubiquitination(2024)8 cited