Indrani W. Gunawardana

Publications by Year

Research Areas

Cancer therapeutics and mechanisms, DNA Repair Mechanisms, Microtubule and mitosis dynamics, Chemical Synthesis and Analysis, Alcoholism and Thiamine Deficiency

Most-Cited Works

• → New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models(2001)66 cited
• → Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species(2013)58 cited
• → Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3-c]pyridines with Fine-Tuning at C-2 Carbamides(2001)56 cited
• → Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors(2007)56 cited
• → Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression(2001)52 cited
• → Non-charged thiamine analogs as inhibitors of enzyme transketolase(2007)40 cited
• → Discovery of 7-Tetrahydropyran-2-yl Chromans: β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β-Protein (Aβ) in the Central Nervous System(2014)38 cited
• → Single-Agent Inhibition of Chk1 Is Antiproliferative in Human Cancer Cell Lines In Vitro and Inhibits Tumor Xenograft Growth In Vivo(2011)25 cited
• → Discovery of Ascomycin Analogs with Potent Topical but Weak Systemic Activity for Treatment of Inflammatory Skin Diseases(1998)24 cited
• → Prodrug thiamine analogs as inhibitors of the enzyme transketolase(2007)24 cited