Kathleen Aertgeerts
Vertex Pharmaceuticals (United States)(US)
Publications by Year
Research Areas
Peptidase Inhibition and Analysis, Neuropeptides and Animal Physiology, Protease and Inhibitor Mechanisms, Blood Coagulation and Thrombosis Mechanisms, Computational Drug Discovery Methods
Most-Cited Works
- → Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein(2011)417 cited
- → High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875(2014)343 cited
- → Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins(2003)297 cited
- → Structural and Kinetic Analysis of the Substrate Specificity of Human Fibroblast Activation Protein α(2005)277 cited
- → Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold(2011)211 cited
- → Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation(2004)210 cited
- → The Low Density Lipoprotein Receptor-related Protein Is a Motogenic Receptor for Plasminogen Activator Inhibitor-1(2004)196 cited
- → Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV(2010)124 cited
- → Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain(2025)120 cited
- → Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives(2013)112 cited