Nobuo Shimma
Publications by Year
Research Areas
Melanoma and MAPK Pathways, Computational Drug Discovery Methods, Synthesis and biological activity, Cancer therapeutics and mechanisms, Cancer Treatment and Pharmacology
Most-Cited Works
- → Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue(1998)1,233 cited
- → Host sphingolipid biosynthesis as a target for hepatitis C virus therapy(2005)176 cited
- → Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity(2013)163 cited
- → The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine(2000)135 cited
- → Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors(2002)131 cited
- → Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments(2011)128 cited
- → Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase(2003)119 cited
- → Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N -myristoyltransferase. Part 1(2001)116 cited
- → Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3(2003)98 cited
- → Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole(2003)82 cited