Paul Depledge
University of Manchester(GB)Cancer Research UK Manchester Institute(GB)
Publications by Year
Research Areas
Cancer therapeutics and mechanisms, Drug Transport and Resistance Mechanisms, PI3K/AKT/mTOR signaling in cancer, Malaria Research and Control, Microbial Natural Products and Biosynthesis
Most-Cited Works
- → The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer(2008)741 cited
- → Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance(2004)79 cited
- → Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II(2013)61 cited
- Malarial parasites and tumour cells are killed by the same component of tumour necrosis serum.(1984)
- → Differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factor(1982)57 cited
- → Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf(2012)50 cited
- → Design and Synthesis of New Templates Derived from Pyrrolopyrimidine as Selective Multidrug-Resistance-Associated Protein Inhibitors in Multidrug Resistance(2004)44 cited
- → Studies on Quinazolinones as Dual Inhibitors of Pgp and MRP1 in Multidrug Resistance(2002)38 cited
- Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.(2012)
- → Novel β-Methoxyacrylates of the 9-Methoxystrobilurin and Oudemansin Classes Produced by the Basidiomycete Favolaschia pustulosa(1996)29 cited