Gerard M. Koether
Wilmington University(US)AstraZeneca (United States)(US)
Publications by Year
Research Areas
Receptor Mechanisms and Signaling, Neuropeptides and Animal Physiology, Pharmacological Receptor Mechanisms and Effects, Computational Drug Discovery Methods, Enzyme Structure and Function
Most-Cited Works
- → Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency(2007)211 cited
- → Design, Synthesis, and SAR of Tachykinin Antagonists: Modulation of Balance in NK1/NK2 Receptor Antagonist Activity(2002)51 cited
- → Discovery of novel, orally active dual NK1/NK2 antagonists(2001)39 cited
- → Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties(2004)30 cited
- → 4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators(2010)27 cited
- → Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1(2010)26 cited
- → Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists(2004)21 cited
- → SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2(2010)19 cited
- → Synthesis and SAR of sulfoxide substituted carboxyquinolines as NK3 receptor antagonists(2010)13 cited
- → 2-Azolyl-4-Benzylpyrimidine Herbicides: Novel Inhibitors of Carotenoid Biosynthesis Part II(2001)3 cited