Paul A. Bethel
AstraZeneca (Poland)(PL)
Publications by Year
Research Areas
Synthesis and biological activity, Synthesis and Biological Evaluation, Synthesis and Characterization of Heterocyclic Compounds, Protease and Inhibitor Mechanisms, Synthetic Organic Chemistry Methods
Most-Cited Works
- → Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor(2014)591 cited
- → Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)(2013)258 cited
- → Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)(2019)77 cited
- → Dipeptidyl nitrile inhibitors of Cathepsin L(2009)67 cited
- → Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point(2017)52 cited
- → Reactions of organotin tetrazoles: synthesis of functionalised poly-tetrazoles(1999)45 cited
- → Design of selective Cathepsin inhibitors(2009)33 cited
- → A formal synthesis of (+)-pyripyropene A using a biomimetic epoxy-olefin cyclisation: effect of epoxy alcohol/ether on cyclisation efficiency(1999)21 cited
- → A formal synthesis of (+)-pyripyropene A using a biomimetic epoxy-olefin cyclisation(1999)20 cited
- → Optimized scale up of 3-pyrimidinylpyrazolo[1,5-a]pyridine via Suzuki coupling; a general method of accessing a range of 3-(hetero)arylpyrazolo[1,5-a]pyridines(2012)19 cited