Edwin J. Iwanowicz

Publications by Year

Research Areas

Cancer, Hypoxia, and Metabolism, Mitochondrial Function and Pathology, Peptidase Inhibition and Analysis, RNA modifications and cancer, Biochemical and Molecular Research

Most-Cited Works

• → Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues(2019)197 cited
• → A mild and efficient method for the preparation of guanidines(1992)132 cited
• → Preparation ofN,N'-bis-tert-Butoxycarbonylthiourea(1993)82 cited
• → The synthesis of either (+) or (−) trans-2,5-dimethylpyrrolidine(1987)57 cited
• → Imidazoquinoxaline Src-Family Kinase p56Lck Inhibitors: SAR, QSAR, and the Discovery of (S)-N-(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity(2004)55 cited
• → Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1(2006)51 cited
• → Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase: Discovery and SAR Leading to the Identification of N-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)(2007)49 cited
• → An enantio- and erythro-selective lithium enolate derived from a vinylogous urethane: its application as a C4 synthon to the virginiamycin M2 problem(1986)47 cited
• → Highly diastereoselective alkylation reactions of vinylogous urethanes derived from simple tetronic acids(1988)43 cited
• → Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome(2022)43 cited