Osvaldo dos Santos
Publications by Year
Research Areas
PI3K/AKT/mTOR signaling in cancer, Molecular Sensors and Ion Detection, Quinazolinone synthesis and applications, Synthesis and Biological Evaluation, Phenothiazines and Benzothiazines Synthesis and Activities
Most-Cited Works
- → Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor(2010)211 cited
- → Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor(2011)169 cited
- → Geometry-Dependent Phosphodiester Hydrolysis Catalyzed by Binuclear Copper Complexes(2003)81 cited
- → Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates(2004)79 cited
- → Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402(2009)78 cited
- → PKI-179: An orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor(2010)71 cited
- → 2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer(2009)69 cited
- → 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases(2007)66 cited
- → Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor(2010)59 cited
- → Sulfonation and anticoagulant activity of botryosphaeran from Botryosphaeria rhodina MAMB-05 grown on fructose(2009)54 cited