Paul D. Kemmitt

Publications by Year

Research Areas

Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Catalytic C–H Functionalization Methods, Catalytic Cross-Coupling Reactions, Crystallography and molecular interactions

Most-Cited Works

• → Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor(2014)591 cited
• → Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6(2018)136 cited
• → Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy(2021)90 cited
• → Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C(2020)83 cited
• → Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors(2017)78 cited
• → Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor(2009)75 cited
• → Making medicinal chemistry more effective—application of Lean Sigma to improve processes, speed and quality(2009)69 cited
• → Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C(2022)60 cited
• → 1—Azatriene cyclisation as a route to annelated pyrido[4,3-b]indoles(1997)49 cited
• → Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers(2016)47 cited