Crystal N. Doty
Pacific Centre for Reproductive Medicine(CA)
Publications by Year
Research Areas
Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Muscle Physiology and Disorders, Ion channel regulation and function, Fungal and yeast genetics research
Most-Cited Works
- → Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin(2006)647 cited
- → Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin(2011)289 cited
- → HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia(2011)165 cited
- → Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS(2013)158 cited
- → In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides(2014)146 cited
- → HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity(2015)132 cited
- → Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus(2008)128 cited
- → A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease(2015)126 cited
- → Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease(2018)123 cited
- → Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients(2014)113 cited