Yelena Sarkisova
Publications by Year
Research Areas
Lung Cancer Treatments and Mutations, Quinazolinone synthesis and applications, Protein Kinase Regulation and GTPase Signaling, Nerve injury and regeneration, Ubiquitin and proteasome pathways
Most-Cited Works
- → Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials(2013)408 cited
- → Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models(2012)96 cited
- → Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma(2020)26 cited
- → Abstract B232: Activity of a potent and selective phase I ALK inhibitor LDK378 in naive and crizotinib-resistant preclinical tumor models.(2011)18 cited
- → Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors(2021)8 cited
- → Abstract LB242: Discovery and characterization of BRSD-143, an orally bioavailable panKRAS inhibitor(2025)