Bruce M. Bechle
Pfizer (United States)(US)
Publications by Year
Research Areas
Asymmetric Synthesis and Catalysis, Chemical Synthesis and Analysis, Synthesis and Catalytic Reactions, Synthesis and biological activity, Receptor Mechanisms and Signaling
Most-Cited Works
- → Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia(2012)89 cited
- → Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7(2017)83 cited
- → A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19(2024)61 cited
- → Benzyloxazolidine-2,4-diones as potent hypoglycemic agents(1991)60 cited
- → Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists(2009)51 cited
- → Identification of Tricyclic Analogs Related to Ellagic Acid as Potent/Selective Tyrosine Protein Kinase Inhibitors(1994)45 cited
- → Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain(2018)38 cited
- → Selective inhibition of the tyrosine kinase pp60src by analogs of 5,10-dihydropyrimido[4,5-b]quinolin-4(1H)-one(1995)33 cited
- → PF-04859989 as a template for structure-based drug design: Identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency(2013)31 cited
- → Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes(2017)27 cited