S. Igaki
Takeda (Japan)(JP)
Publications by Year
Research Areas
Lung Cancer Treatments and Mutations, HER2/EGFR in Cancer Research, Bacterial Genetics and Biotechnology, Epigenetics and DNA Methylation, RNA and protein synthesis mechanisms
Most-Cited Works
- → Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors(2012)163 cited
- → Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins(2013)108 cited
- → Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole(2021)93 cited
- → Newly identified genes involved in the signal transduction of Escherichia coli K-12(1994)81 cited
- → T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice(2018)45 cited
- → Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors(2012)37 cited
- → LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models(2021)37 cited
- → Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein–Protein Interaction Interface(2018)22 cited
- Cloning and sequence analysis of the evgAS genes involved in signal transduction of Escherichia coli K-12.(1992)
- → EGFR Kinase domain T790M/L858R mutant with compound 2(2012)