Safura Babu‐Khan
Amgen (United States)(US)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Drug Transport and Resistance Mechanisms, Computational Drug Discovery Methods, Cholinesterase and Neurodegenerative Diseases, Protein Structure and Dynamics
Most-Cited Works
- → β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE(1999)3,800 cited
- → Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation(2001)991 cited
- → Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease(2003)469 cited
- → Expression Analysis of BACE2 in Brain and Peripheral Tissues(2000)309 cited
- → Cloning of a mineral phosphate-solubilizing gene from Pseudomonas cepacia(1995)190 cited
- → Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid(2012)64 cited
- → Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors(2012)41 cited
- → A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase(2012)28 cited
- → Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease(2013)15 cited
- → Establishing the Relationship between In Vitro Potency, Pharmacokinetic, and Pharmacodynamic Parameters in a Series of Orally Available, Hydroxyethylamine-Derived β-Secretase Inhibitors(2012)11 cited