Alexander L. Breeze
University of Leeds(GB)
Publications by Year
Research Areas
Fibroblast Growth Factor Research, Protein Structure and Dynamics, Protein Kinase Regulation and GTPase Signaling, Computational Drug Discovery Methods, Enzyme Structure and Function
Most-Cited Works
- → Isotope-filtered NMR methods for the study of biomolecular structure and interactions(2000)201 cited
- → Fragment screening to predict druggability (ligandability) and lead discovery success(2011)200 cited
- → Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation(2012)169 cited
- → Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase(1992)167 cited
- → The high-resolution crystal structure of a 24-kDa gyrase B fragment fromE. coli complexed with one of the most potent coumarin inhibitors, clorobiocin(1997)150 cited
- → Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents(2011)134 cited
- → An Integrated Approach to Fragment-Based Lead Generation:Philosophy, Strategy and Case Studies from AstraZenecas Drug Discovery Programmes(2007)127 cited
- → Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4(2014)119 cited
- → Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation(2015)118 cited
- → Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use(2016)115 cited