Nolan Dewdney
La Roche College(US)
Publications by Year
Research Areas
Synthesis and biological activity, Protease and Inhibitor Mechanisms, Melanoma and MAPK Pathways, Peptidase Inhibition and Analysis, Biochemical Acid Research Studies
Most-Cited Works
- → Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis(2014)107 cited
- → Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase(2011)74 cited
- → Acyloin formation by benzoylformate decarboxylase from Pseudomonas putida(1992)72 cited
- → Novel indolactam-based inhibitors of matrix metalloproteinases(1995)53 cited
- → Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2′-P3′ amide bond isostere(1996)37 cited
- → Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides(1992)32 cited
- → 3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a highly selective lead(2011)27 cited
- → Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs(2003)19 cited
- → Synthesis of Heteroaryl-fused Pyrazoles as P38 Kinase Inhibitors(2009)8 cited
- → Enantiospecific Production of S-(-)-2-Hydroxypropiophenone Mediated by Benzoylformate Decarboxylase fromAcinetobacter Calcoaceticus(1993)7 cited