Xinjun Hou
East China Jiaotong University(CN)Pfizer (United States)(US)Zhejiang University(CN)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Protein Structure and Dynamics, Receptor Mechanisms and Signaling, Cholinesterase and Neurodegenerative Diseases, Phosphodiesterase function and regulation
Most-Cited Works
- → Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties(2010)1,010 cited
- → Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery(2016)578 cited
- → Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes(2010)479 cited
- → Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis(2020)238 cited
- → Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).(2009)201 cited