James R. Kiefer
Publications by Year
Research Areas
Estrogen and related hormone effects, Inflammatory mediators and NSAID effects, Peptidase Inhibition and Analysis, Protein Degradation and Inhibitors, DNA and Nucleic Acid Chemistry
Most-Cited Works
- → Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal(1998)520 cited
- → An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells(2016)345 cited
- → A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385(2003)344 cited
- → The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life(2010)326 cited
- → Structural insights into the stereochemistry of the cyclooxygenase reaction(2000)272 cited
- → Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6(2010)224 cited
- → Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen(2010)220 cited
- → Structural basis for dual-mode inhibition of the ABC transporter MsbA(2018)174 cited
- → Crystal structure of a thermostable Bacillus DNA polymerase l large fragment at 2.1 Å resolution(1997)158 cited
- → GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer(2021)132 cited