Huai-Xiang Hao
Publications by Year
Research Areas
Protein Tyrosine Phosphatases, Melanoma and MAPK Pathways, Tuberous Sclerosis Complex Research, Lung Cancer Treatments and Mutations, PI3K/AKT/mTOR signaling in cancer
Most-Cited Works
- → ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner(2012)960 cited
- → Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases(2016)909 cited
- → Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma(2013)416 cited
- → SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors(2018)200 cited
- → Capmatinib (INC280) Is Active Against Models of Non–Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation(2019)173 cited
- → Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer(2016)172 cited
- → R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5(2012)171 cited
- → 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors(2019)86 cited
- → Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus(2015)79 cited
- → SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms(2021)72 cited