George D. Mcilroy

Publications by Year

Research Areas

Nuclear Structure and Function, Retinoids in leukemia and cellular processes, Adipose Tissue and Metabolism, Antioxidant Activity and Oxidative Stress, Diabetes and associated disorders

Most-Cited Works

• → Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction(2010)146 cited
• → Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein(2011)81 cited
• → Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus(2012)69 cited
• → Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis(2012)64 cited
• → The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes(2014)55 cited
• → Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease(2018)44 cited
• → Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue(2015)41 cited
• → Production of reactive oxygen species by the mitochondrial electron transport chain in Drosophila melanogaster(2010)39 cited
• → Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation(2020)35 cited
• → Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice(2017)34 cited