John P. Umland
Pfizer (United States)(US)
Publications by Year
Research Areas
Phosphodiesterase function and regulation, Drug Transport and Resistance Mechanisms, Pharmacogenetics and Drug Metabolism, Cholinesterase and Neurodegenerative Diseases, Computational Drug Discovery Methods
Most-Cited Works
- → Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase(2003)544 cited
- → Development of a new permeability assay using low‐efflux MDCKII cells(2011)314 cited
- → Species Independence in Brain Tissue Binding Using Brain Homogenates(2011)160 cited
- → Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret(1996)143 cited
- → High Throughput ADME Screening: Practical Considerations, Impact on the Portfolio and Enabler of In Silico ADME Models(2008)84 cited
- → Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: “SLC-Phenotyping” Using Primary Human Hepatocytes(2019)78 cited
- → Impact of Recovery on Fraction Unbound Using Equilibrium Dialysis(2011)59 cited
- → GM-CSF rapidly primes mice for enhanced cytokine production in response to LPS and TNF(1995)46 cited
- → In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier(2019)46 cited
- → Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [3H]rolipram binding site(1995)45 cited