David J. Calderwood

Publications by Year

Research Areas

Synthesis and Biological Evaluation, Synthesis and biological activity, Quinazolinone synthesis and applications, Protein Kinase Regulation and GTPase Signaling, Melanoma and MAPK Pathways

Most-Cited Works

• → Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I(2000)93 cited
• → Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection(2005)84 cited
• → Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases(2010)80 cited
• → Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck — a selectivity insight(2002)76 cited
• → A-770041, a Novel and Selective Small-Molecule Inhibitor of Lck, Prevents Heart Allograft Rejection(2005)65 cited
• → Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck(2002)53 cited
• → Pyrrolo[2,3-d]pyrimidines Containing an Extended 5-Substituent as Potent and Selective Inhibitors of lck II(2000)51 cited
• → A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection(2004)40 cited
• → Organocerium reactions of benzamides and thiobenzamides: A direct synthesis of tertiary carbinamines(1997)30 cited
• → 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode(2009)26 cited