Jens Niewoehner
Roche (Switzerland)(CH)Roche Pharma AG (Germany)(DE)
Publications by Year
Research Areas
Monoclonal and Polyclonal Antibodies Research, Asthma and respiratory diseases, Alzheimer's disease research and treatments, Barrier Structure and Function Studies, Erythrocyte Function and Pathophysiology
Most-Cited Works
- → Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle(2014)588 cited
- → A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding(2014)148 cited
- → Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans(2023)141 cited
- → Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode(2018)102 cited
- → TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+CD161+ T cells to exacerbate gut inflammation(2012)78 cited
- → Brain Shuttle Neprilysin reduces central Amyloid-β levels(2020)60 cited
- → Thymic stromal lymphopoietin receptor blockade reduces allergic inflammation in a cynomolgus monkey model of asthma(2013)58 cited
- → Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays(2021)54 cited
- → Expression and localization of claudins-3 and -12 in transformed human brain endothelium(2012)50 cited
- → Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct(2023)36 cited